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No significant difference in the prevalence of symptoms was found between participants with MMA levels 400 nmol/l (n = 60) and those whose levels were 600 nmol/l showed some improvement in neurological symptoms (Hvas, 2001b)

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It has been extensively characterised in preclinical in-vitro and in-vivo models for its cytoprotective, angiogenic, and anti-inflammatory properties across a range of tissue types

Preclinical studies suggest it promotes angiogenesis (new blood vessel formation), collagen synthesis, and modulation of nitric oxide pathwayskey steps in tissue repair