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Cocaine and depression Cocaine is a natural stimulant derived from the coca plant, used both recreationally and as a local anesthetic 67

In normoxia conditions, HIF-1 is oxidized (hydroxylated) by prolyl hydroxylases (PHDs) with -ketoglutarate derived from the tricarboxylic acid (TCA) cycle, which becomes ubiquitinated, then catabolized by proteasomes