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These CpG islands have either methylated or hydroxymethylated cytosines as 5-methyl cytosine (5mC) and 5-methyl hydroxy cytosine (5hmC) [58,59,60]

Nature 547 , 453457 (2017) Fan, W

Additionally, pyridoxine therapy alone does not reduce fasting homocysteine and the reduction in postmethionine-load homocysteine levels was smaller for pyridoxine than for the combined therapy using folic acid and pyridoxine (van der Griend et al, 2000)