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If density declines significantly, interventions include calcium and vitamin D optimization, weight-bearing exercise, and sometimes pharmacologic therapy

tested the effects of a multispecies probiotic on innate immune function, bacterial translocation, and intestinal permeability in a randomized placebo-controlled clinical trial in patients with cirrhosis and demonstrated an increase in serum neopterin levels and production of ROS by neutrophils, and some improvement in liver function in patients treated with probiotics