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PubMed Central , Environmental Research , vol

By exploiting the mouse machinery for antibody diversification and selection and the lack of immunological tolerance to human proteins, the reproduced human antibody repertoire in these mouse strains should yield high affinity antibodies against any antigen of interest, including human antigens

In order to mirror chronic administration in clinical populations, the number of chronic dosage regimens in animal studies should also be enhanced

To soak up excess ammonia, charcoal flushes can also be used, followed by magnesium citrate 1-2 times weekly