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Bridges R, Lutgen V, Lobner D, Baker DA (2012) Thinking outside the cleft to understand synaptic activity: contribution of the cystine-glutamate antiporter (System xc-) to normal and pathological glutamatergic signaling

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At the signaling level, the cascade initiated by ipamorelin binding to GHS-R1a involves phospholipase C activation and inositol trisphosphate (IP3) generation, leading to calcium release from intracellular stores a pathway distinct from the GHRH receptor, which primarily signals through cyclic AMP

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