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Nature 358(6381):1516

Specifically, Prevotella copri produces succinic acid, which binds to succinate receptors on dendritic cells, enhancing antigen-specific T cell responses and contributing to host immune defense mechanisms (Dan et al., 2020)

Despite these advances, translation into clinical practice remains limited due to challenges such as immunogenicity, systemic instability, manufacturing scalability, and regulatory complexity

Less common: joint stiffness (usually resolves), carpal tunnel symptoms at higher doses, mild fasting glucose elevation

discovered that in mouse MCs, knocking down ROCK restored impaired fatty acid metabolism by modulating metabolic regulators like AMPK, PGC-1, and CPT-1 [78]