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[DOI] [PubMed] [Google Scholar] 139.Mass PG, Mahuren JD, Tranchant C, Dosy J

At present, the only definitive cure is bone marrow transplant ( UHs are a group of congenital disorders caused by mutations in globin genes leading to destabilization of hemoglobin (Hb) molecules as a consequence of (a) amino acid substitutions within the heme pocket, (b) disruption of secondary structure, (c) substitution in the hydrophobic interior of the subunit, (d) amino acid deletions, and (e) elongation of the subunit