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However, there are currently no suitable medicines or agonists that can directly induce GPX3 expression, and many researchers have constructed overexpression plasmids to increase GPX3 expression in cells [50]

In this context, lifestyle, gender, drugs, age, and microbiota have a synergistic impact on the levels of TMAO ( Figure 2 The mechanism of TMAO leading to CVDs The mechanism of TMAO resulting in atherosclerosis, HF, and hypertension has gradually been clarified ( Supplementary Table 3 )