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By inhibiting NNMT, it can increase intracellular NAD+ levels, activate longevity proteins SIRT1/SIRT3, enhance mitochondrial function and fat metabolism, and is widely used in metabolic regulation, obesity, insulin resistance and aging-related scientific research experiments

Nutritional Neuroscience 17 (4): 156163

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The NNMT-NAD+-Sirtuin Axis: How 5-Amino-1MQ Connects to Longevity Research The most scientifically compelling aspect of this compound is its mechanistic connection to the NAD+-sirtuin axis the same pathway that drives the enormous research interest in NAD+ supplementation, NMN, and NR