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This intensity gated systemic redox signaling model is illustrated in Figure 6, where the signal is released into the blood stream in response to the high intensity exercise and activates Nrf2 signaling in the contralateral unstimulated muscle, while low intensity muscle stimulation does not meet the threshold to propagate a systemic redox signaling response

Ethics declarations Ethics Approval All experiments involving animals were carried out in accordance with NIH guidelines and were approved by the University of Selcuk Animal Care and Use Committee (Protocol Number: 201828)

Dexamethasone-induced oxidative stress enhances myeloma cell radiosensitization while sparing normal bone marrow hematopoiesis