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High-dose vitamin E supplements may interfere with blood clotting, cause hemorrhages, and lead to hemorrhagic stroke (22)

Its also essential for the production of DNA and red blood cells

Individuals with B12 deficiency often report symptoms similar to those of anxiety and depression, such as irritability and cognitive difficulties

Brachs S, Polack J, Brachs M, Jahn-hofmann K, Elvert R, Pfenninger A, Brenz F, Margerie D, Mai K, Spranger J, Kannt A (2018) Genetic Nicotinamide N -Methyltransferase (Nnmt) deficiency in male mice improves insulin sensitivity in diet-induced obesity but does not affect glucose tolerance