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Concurrently, the level of Bifidobacterium in the GM of ALD patients is also lower than that in healthy individuals

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Cell Stem Cell 18 , 229242 (2016)

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As specifically demonstrated in recent studies on FXN -deficient DRG neurons and patient fibroblasts, treatment with omaveloxolone successfully drives the upregulation of Nrf2 and the GPx4 enzymatic shield

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Retrospective application of a set of clinical diagnostic criteria for the diagnosis of multiple system atrophy

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142 Additionally, inhibition of COX17 leads to elevated mitochondrial copper levels in leukemic stem cells, which results in reduced cellular levels of S-adenosylmethionine, subsequently decreasing global DNA methylation and increasing chromatin accessibility, which contributes to promoting the differentiation of acute myeloid leukemia cells while reducing stem cell-like characteristics

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