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Multivariable analysis: We included demographic, etiology, prior hospitalizations, PPI, SBP prophylaxis, HE, ascites, Oral health (no

doi:10.1038/s41598-022-09346-y

Expression analysis and heat map construction Expression data of SlGST transcripts was retrieved from genevestigator ( [42] at various anatomical tissues, developmental stages and in response to different biotic and abiotic stress conditions (S1 Data)

Prevention: How to Minimize Future Exposure Choose low-mercury fish and rotate seafood choices Filter your water for heavy metals Test for mercury if you have symptoms or risk factors Avoid unnecessary amalgam use or mercury-containing products Support regular detoxification through nutrition, hydration, and movement Conclusion Mercury toxicity remains one of the most underdiagnosed contributors to chronic illness

Collectively, our study identifies the L2HGDH-L2HG axis as a previously unrecognized metabolic checkpoint controlling ferroptosis sensitivity in liver cancer and uncovers glutathione degradation as a therapeutically exploitable vulnerability for ferroptosis-based treatment strategies in HCC