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The drugs istradefylline, preladenate, and tozadenate have been tested in phase 2b and phase 3 clinical trials and were potent and highly selective A2A receptor antagonists with good CNS penetration (Brooks et al., 2010

In the future, in-depth analysis of the ASCT2 3D structure using structural biology techniques and an in-depth understanding of the interaction mechanism between ASCT2 and inhibitors will help to optimize the structure of inhibitors and improve their efficacy

Different from most previous studies, the present work showed that the APP treatment-induced changes in the serum ROS levels were much smaller than those induced by plasma in saline, and the extent of plasma-induced change in the NO level differed slightly between saline and serum, implying the potential antioxidant properties of the plasma-treated serum

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