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The lack of success at Phase III was attributed to factors such as high baseline immunosuppressive therapy in patients and complex disease mechanisms in SLE, potentially limiting the application of Rituximab as a monotherapy in SLE (119)

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Inhibitors of GGT Glutamine analogs including acivicin, 6-diazo-5-oxo- l -norleucine, and l -azaserine inhibit GGT (Tate and Meister, 1978)

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