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10.1523/JNEUROSCI.5783-10.2011 161 PlaitakisA.Kalef-EzraE.KotzamaniD.ZaganasI.SpanakiC

We do not treat patients with a known hypersensitivity to cobalamin or cobalt, patients with a rare condition called Leber's optic atrophy, or patients who are pregnant or breastfeeding without GP sign-off

Patients with CD may present orofacial granulomatosis, as symptomatic oral disease, and other oral manifestation derived from qualitative changes in salivary composition (32)