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Enhancing GSH synthesis, selenium levels and redox-active selenoproteins, and activating Nrf2 and other antioxidant enzymes will strengthen the cardiovascular antioxidant defense

Oncogene (2021) 40:201834

12-( S )-HETE: 12-( S )-hydroxyeicosatetraenoic acid

Additionally, they suppress the NLRP3 inflammasome, downregulating IL-1 and mitigating inflammatory responses (Qiu et al., 2023)

Pre-treatment with notoginsenoside R1 from Panax notoginseng protects against high-altitude-induced pulmonary edema by inhibiting pyroptosis through the NLRP3/caspase-1/GSDMD pathway