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In MASLD, elevated CCL2 levels exacerbate liver inflammation by enhancing monocyte and macrophage infiltration [196]

In certain embodiments antibody-drug conjugates (ADCs) are provided that comprise an anti-ALPP/ALPPL2 antibody attached to a cytotoxic/cytostatic drug, for example a drug that has activity against both dividing and resting tumor cells, such as DNA chelating agents