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Description

Herein, we present a versatile method for the direct functionalisation of readily available amino-modified oligonucleotides (AONs), where a 5-hydroxy-1,5-dihydro-2H-pyrrol-2-ones (5HP2O) Michael acceptor is directly formed in a rapid and efficient manner on a free primary amine

The exact timing varies based on individual factors including blood flow to the injection site, subcutaneous tissue thickness, and metabolic rate

Handb Clin Neurol 129:325 Polski B, Sosnowska-Sienkiewicz P, Szydowski J, Januszkiewicz-Lewandowska D (2023) Applications of the grading scales for the detection of ototoxicity in children after treatment of neuroblastoma and extracranial germinal tumor