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Patients who did not respond to IFN therapy were treated with sequential low-dose IL-2 for 6 months

Inhibition activities were measured as described ( Activation and Inhibition of 12-LOX and 15-LOX in Cell-Free Assays The enzyme activities of 12-LOX and 15-LOX were assessed spectrophotometrically by measuring the formation of 12-HpETE and 15-HpETE, respectively