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3.4 The functional significance of alternative programmed cell death modalities in oncogenesis and therapeutic interventions Programmed cell death, a genetically regulated active cellular termination process, plays an essential role in the development and maintenance of homeostasis in multicellular organisms and can be classified into apoptotic and non-apoptotic modalities

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The molecular regulators of metabolic reprogramming, which are crucial for developing novel therapeutic strategies, however, remain largely unknown

Melatonin is an indolamine and neurohormone secreted rhythmically by the pineal gland

It has been shown that PL can selectively induce the death of head and neck cancer cells and increase cisplatin antitumor activity, involving the JNK and PARP death pathways [196]