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In vitro and animal studies suggest roles in tendon-to-bone healing, intestinal mucosal repair, and ligament recovery, with the nitric oxide system proposed as a key mediator

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By upregulating key genes such as interleukin-17 (IL-17) and retinoic acid receptor-related orphan receptor gamma t (RORt), which are essential for Th17 cell differentiation and inflammation regulation, STAT3 effectively amplifies the inflammatory cascade reaction (Parihar and Bhatt, 2023)