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In pregnant women in Pune, India, total homocysteine (tHcy) concentrations in pregnancy were significantly and inversely associated with birth weight, adjusting for maternal weight, height, gestational age, and infant sex (11)

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Indeed, in most patients with folate deficiency a nutritional element is present

This means most of a high-dose supplement remains in the gastrointestinal tract, though the direct link to digestive symptoms is not well established

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