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Consequently, nox1 mutants display an overall marked increase in the levels of free amino acids, including L-arginine, a precursor of NO 24 (Supplementary Fig

This effect is mediated by GSH-dependent conjugation and export of anticancer drugs, diminishing their intracellular concentrations and therapeutic efficacy (5053)

Moreover, a holistic and personalized approach (considering genomics) can address all the comorbidities to improve and optimize overall health outcomes in CKD