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Several studies have concluded that the brains of AD patients, when compared with age-matched controls, show higher levels of reactive oxygen species-generating elements, such as iron, 45 47 higher concentrations of protein oxidation biomarkers, 48 , 49 a greater extent of oxidative neuronal DNA damage, 50 , 51 and increased production of malondialdehyde from lipid peroxidation

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However, in many areas of research, repurposed drugs may not be effective in clinical trials or may not maintain the benefit-injury equilibrium (Fetro and Scherman, 2020)

Statements Author contributions LZ: Methodology, Investigation, Data curation, Writingoriginal draft