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Tonum cites human clinical trial data reporting about a 10.4% average weight loss over six months and notes that most of the loss was fat rather than lean mass

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SIRT3-5 are located in mitochondria, and SIRT3 has also been found to upregulate the deacetylated levels of PGC-1 and Long-Chain Acyl-CoA Dehydrogenase (Mohan et al