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Curcumin upregulates the Nrf2 system by repressing inflammatory signaling-mediated Keap1 expression in insulin-resistant conditions

It is primarily involved in mood regulation, emotion, and cognition (Arnone et al

There is so far no inflammatory marker that has been systematically found in PAIS, but it should be remembered that a persistent inflammation affecting an organ, e.g., neuroinflammation, may remain local and may only minimally be reflected in blood biomarkers

Phytosomes are well suited for oral and topical administration and preparation techniques such as solvent evaporation, rotary evaporation, and lyophilization are commonly employed to bind plant extracts with phospholipids for improved pharmacokinetic properties and targeted therapeutic effects [89, 90]

PMC 1470061