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2.Savory LA, kerr CJ, Whiting P, Finer N, McEneny J, Ashton T

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MAP1A protein expression in AML (n = 162 patients) and control health bone-marrow samples (n = 10 patients)

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Notably, numerous mechanistic studies have revealed p53 independent ytotoxic effects of PRIMA-1 and APR-246, mediated by adduct formation with intracellular glutathione, thus leading to increased reactive oxygen species (ROS) production and triggering oxidative stress (67)