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Thiopurines should be used with caution in smokers, as long-term smoking can upregulate CYP450 that can cause demethylation of meMP, potentially leading to a greater proportion of the drug being converted to 6-TGN, though this has not been clinically proven (Warner et al., 2016)

Front Immunol 10:549 Hameed S, Xie L, Ying Y (2018) Conventional and emerging detection techniques for pathogenic bacteria in food science: a review

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The individual and societal burden of chronic pain in Europe: the case for strategic prioritisation and action to improve knowledge and availability of appropriate care