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This binding causes the gate-like ion channels to open, which allows ions to flow into the cell (10)

That range is technically accurate but practically useless

An evaluation of the role of TDLN in PD-1/PD-L1 checkpoint blockade therapy in two mouse tumor models reveals that immune checkpoint treatment induces CD8+ T cell accumulation in the tumor-draining but not in non-draining LNs (210)abrogated checkpoint therapy, suggesting that TDLNs function as sites of T cell invigoration required for PD-1/PD-L1 checkpoint blockade therapy (211, 212)

For instance, in Alicyclobacillus acidoterrestris , The DnaK gene is induced to express under heat stress, which produces heat shock proteins (HSPs) to shield the microorganism from thermal damage

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