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Cell subpopulations with high OXPHOS activity consistently exhibit greater drug resistance, suggesting that mitochondrial metabolic heterogeneity may serve as a critical biomarker for resistance stratification and therapeutic classification [66]

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In contrast, Hong Guo 1 exhibited the lowest resveratrol content (0.95 mg/g), which was not significantly different from Su Bai Shen, Lv Shen Zi 2, Gui Hua Mi, Tian Sang 202, Da Ma Ya, and Ju Shen

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Levels of glutathione synthetase (GSS) were determined using Human Glutathione Synthetase ELISA Kit (Abcam, Cambridge, UK), while levels of glutathione (GSH) were determined with the GSH+GSSG / GSH Assay Kit (Colorimetric) (Abcam, Cambridge, UK)