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IL-6 programs T(H)-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways

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2024, Nov, 21

Critical iron-regulatory genes that are upregulated by HIF-1, including FTH, TFR1 and DMT1, highlight the intrinsic relationship between iron metabolism and hypoxia as a fundamental aspect of cancer cell adaptation within the tumor microenvironment [88]