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6 The origin and propagation of neurogenic muscle cramps localizes to peripheral and central targets (Figure 1), including the neuromuscular junction, where mechanical disruption and electrolyte disturbances can influence hyperexcitability and cramp generation

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For example, plants such as almonds, fruits, and beans can release cyanide, which is cardiotoxic 62

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[1] Unlike amphetamine abuse, where drug tolerance necessitates escalating doses to achieve the same effect, tolerance to clinically relevant doses of amphetamine plateaus after the initial titration period, and "drug holidays" (i.e., temporary treatment discontinuation) are not required to prevent the development of tolerance