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IC 50(16) = 0.18 M)

-ketoglutarate ( -KG ) derived from the glutaminase-based catabolism of glutamine provides fuel for the tricarboxylic acid cycle (TCA) in pancreatic cancer cells

We next measured levels of methylglyoxal glycation adducts in cells with and without Glo1 expression

Results Chronic ethanol exposure induced earlier and severer cognitive behavioral impairments in APP/PS1 mice To investigate the role of chronic ethanol exposure on cognitive behaviors of wild-type (WT) mice and APP/PS1 mice, continuously increasing ethanol exposure was conducted at three timepoints: 4-week, 8-week, 10-week, and four drinking paradigms: drinking in the dark (DID), two bottle choice (2BC), chronic intermittent ethanol (CIE), and intraperitoneal injection (IP) (Fig