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doi: 10.1002/14651858.CD003538.PUB2 247 NortonRLHoffmannPR

10.1016/j.rmed.2023.107249 119 NemmarA.Al-SalamS.YuvarajuP.BeegamS.AliB

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(9) In addition, curcumin is required to remain in the free-form (biologically active) state to allow passage across the blood-brain barrier in order to initiate its numerous neuroprotective effects

Konopka et al., 2020), cytoplasmic mislocalization of nuclear proteins (Neumann et al., 2006), mitochondrial dysfunction (Albers and Beal, 1997), proteasomal and autophagic dysfunction (Chen et al., 2007