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Description

293 Regulatory factors like histone PARylation factor 1 (HPF1) modulate PARP1 activity during stress-induced DNA damage

Although studies with cereblon-based PROTACs are still scarce, it is expected that long-term clinical use of this type of degrader could lead to the emergence of mutations that prevent PROTAC from binding to cereblon, thus preventing poly-ubiquitination of the target protein