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536 Astrocytic syncytial coupling is also decreased with age, probably reflecting age-dependent down-regulation of connexins expression

We propose that NADPH and GSSG convey TCA cycle status: decreasing the availability of acetyl-CoAeither from lipid or carbohydrate catabolismdampens NADPH production and disfavors glutathione reduction, with the increased GSSG ultimately rendering the ER lumen more oxidizing and protecting ER homeostasis

Kim DH, Kim DJ, Park SJ, Jang WJ,Jeong CH

2018;2:e00034

Odour detectionsensitivity and insensitivity All the information on the biochemistry presented so far refers to the sender: how odour precursors are produced by the host and how commensal bacteria contribute to finally release the volatiles