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Cai B, Zhang Z, Liu K, Fan W, Zhang Y, Xie X, et al

10.1186/s12948-022-00172-1 23 HuL.SunW.TangY.LiS.ZhangB.SunX.et al (2021)

Watson AL, Skepper JN, Jauniaux E, Burton GJ: Changes in concentration, localization and activity of catalase within the human placenta during early gestation

After all, more than 60 percent of the human brain is composed of fat (64)

This perspective explains why early ERmitochondria Ca 2+ maladaptation, later lysosomal-autophagic failure, redox amplification, inflammasome activation, and cell-fate decisions are mechanistically linked, and it generates testable predictions about temporal ordering, reversibility, and disease-stage specificity of contact-site remodeling