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Song XY, Liu PC, Liu WW, et al

doi:10.1021/jm3003203 5

Synergistic and mechanism-driven delivery chemistry strategies The integration of platinum(IV) prodrug technology with PROTACs, exemplified by Li et al.s design of the conjugate CW-2, represents a strategic advance in overcoming the limitations of conventional platinum-based chemotherapy, such as toxicity and resistance [261,262,263,264,265]