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After seven days of treatment, increases persisted in substantia nigra (both compacta and reticulata), lateral caudate, accumbens nucleus, and superior olive

Jin J, Kim SN, Liu X, Zhang H, Zhang C, Seo JS, et al

This work provides compelling evidence for the physiological relevance of MOR biased signalling, as comparing biased signalling with behavioural effects of a range of MOR agonists reveals strong correlation between G i /-arrestin bias factors and the analgesiarespiratory depression therapeutic window

The research here is mechanistically plausible but not directly studied for BPC-157 specifically

The pineal gland (Fig