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guanethidine or rifamycins A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g

Nature (1987) 325(6106):7336.10.1038/325733a0 107 GlennerGGWongCW

Insulin signaling and glucose metabolism Insulin exerts a central role in hepatic glucose and lipid homeostasis by modulating insulin receptor substrate (IRS)-mediated signaling