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It targets growth hormone release without significantly increasing cortisol or prolactin levels, which are hormones that can cause unwanted side effects like water retention, increased appetite, and elevated stress responses

This results in an overproduction of pro-inflammatory cytokines such as interleukin 6 (IL-6), tumour necrosis factor , adhesion molecules, prostaglandins, and mitogen-activated protein kinase signalling cascades

2024;10:e30726

Mitochondrial calcium and the permeability transition in cell death

Induction of mGlu2 receptors is mediated by acetylation mechanisms that involve transcription factors of the nuclear factor (NF)-B family.