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The prevailing proposal is that electron transport between the two domains is dependent on the disordered and mobile C-terminal loop that terminates with the C596-U597 pair

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Mediterr J Hematol Infect Dis 3:2011067 Castaigne S, Chomienne C, Daniel MT, Ballerini P, Berger R, Fenaux P et al (1990) All-trans retinoic acid as a differentiation therapy for acute promyelocytic leukemia

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Phase II detoxification comprises various conjugation reactions, such as glucuronidation, sulfonation, methylation, and amino acid conjugation

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Following menopause estrone (E) plays an important role, with high levels reportedly synthesised in adipose tissue from the adrenally derived precursor DHEA [54, 55]

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They have evolved independently at least twelve times in different plant families, and function by inhibiting the NA+/K+ ATPase enzyme in animal cells, making the plants that produce them toxic

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