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The compound V-9302, an inhibitor of the glutamine transporter, selectively impedes glutamine uptake in cancer cells while simultaneously enhancing both glutamine assimilation and glutathione synthesis in T eff cells, ultimately enhancing their function

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Hormones (Athens, Greece)

Human transketolase can be used in structure-based drug design as target for inhibition in the treatment of cancer [113] and in the search for new transketolase inhibitors as non permanently charged thiamine analogs,which are substrates for the thiamine activator thiamine pyrophosphokinase

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