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Animal studies suggest high tolerance and no significant toxicity, even at large doses [44]

Mau S, Saermark T

Similarly, ASP2535 demonstrated cognitive benefits in aged rats when administered orally with a dose of 0.1 mg/kg for 4 days, suggesting its potential for counteracting age-related cognitive decline (Harada et al

CMRFs at presentation (BMI, diabetes, dyslipidemia, hypertension) were identified and categorized as 30) with median (IQR) BMI of 32 (30-34), 24% type-2 diabetes, 25% hypertension and 2% dyslipidemia