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We then established a putative gene signature (comprising gclc , gls , gpx4 , gss , slc25a39 , and e2f1 ) of GSH metabolism (GMGS) in association with therapeutic response

This schematic highlights how curcumin disrupts key inflammatory cascades such as the IKK/NF-B pathway, shifts immune cell phenotypes toward anti-inflammatory states, suppresses the expression of pro-fibrotic factors such as TGF- and CTGF, and promotes the apoptosis of inflammatory cells

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