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Depression, characterized by symptoms such as negative mood, persistent low mood, self-depreciation, and loss of interest in life, seriously affects the life and health of individuals

As one of the major producers of ROS, mitochondria are particularly vulnerable to oxidative stress-induced cytotoxicity, especially considering mtDNA is not protected by histone proteins as seen in nuclear DNA (Richter et al., 1988)

Inflamm Res 2005;54:50813

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