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Mitochondrial dysfunction Mitochondria are indispensable organelles responsible for ATP production and coordination of calcium homeostasis, hormone synthesis, signal transduction, and apoptotic regulation 79,80

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Over production of either O 2 and H 2 O 2 has been associated with mitochondrial DNA, protein, and lipid damage, metabolic dysfunction and oxidative stress (Berlett and Stadtman, Mitochondria can be a major source of reactive oxygen species (ROS) in the aerobic cell (Brown and Borutaite, 2 consumed by mitochondria is converted to ROS (Chance et al., 2 saturation, and concentration of the redox active enzyme that can generate ROS

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Collectively, this is achieved by the SCN transmitting two types of regulatory signals to the pineal

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