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accumulation of C16-, C18- and C18:1-carnitine

The researchers then used the blunt end of a surgical tool to gently compress the thinned area, recreating a concussion

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Moreover, both in vitro and in vivo experimentsincluding subcutaneous and orthotopic lung tumor modelsdemonstrated that Cu-DMSA-HA NPs promoted intracellular ROS accumulation, mitochondrial disruption, GSH depletion, and downregulation of glutathione peroxidase 4 (GPX4) expression levels, ultimately triggering ferroptosis in cancer cells

Polymerase chain reaction (PCR) amplification was performed in the presence of 2.25 mM MgCl 2 , 0.08 M of each primer, 0.2 mM dNTP, 1.25 U of Taq polymerase (Roche Diagnostics, Mannheim, Germany) and 5 L of each cDNA to a final volume of 50 L